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研究成果

北海道大学大学院医学研究院　分子生物学教室の研究成果

北海道大学大学院医学研究院　分子生物学教室の研究者たちは数多くの論文を発表してきました。当研究所のスタッフによる注目すべき革新的な論文および記事をお読みください。

2023年の論文               

2023年10月23日更新

Ari Hashimoto , Shigeru Hashimoto

ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity.

Int J Mol Sci.;24(19):14934,2023

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Yamamoto R,Yamada S,Atsumi T,Murakami K,Hashimoto A,Naito S,Tanaka Y,Ohki I, Shinohara Y,Iwasaki N,Yoshimura A, Jing-Jing Jiang,Kamimura D,Hojyo S,Kubota SI, Hashimoto S, and Murakami M. 

Computer model of IL-6 dependent rheumatoid arthritis in F759 mice.Int Immunol;35(9):403-421,.2023

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Shirakawa R, Nakajima T, Yoshimura A, Kawahara Y, Orito C, Yamane M, Handa H, Takada S, Furihata T, Fukushima A, Ishimori N, Nakagawa M, Yokota I, Sabe H, Hashino S, Kinugawa S, Yokota T.

Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults.Scientific Reports (13),5203 ,2023)

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Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J, Nishino K, Tatsuta D, Natsui H, Kadosaka T, Koya T, Nakao M, Hagiwara H, Kamada R, Temma T, Tanaka S, Anzai T.

Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats.Frontiers in Cardiovascular Medicine.Front Cardiovasc Med:10:1005408,2023

2022年の論文　　

2022年10月17日更新

Hashimoto A,Handa H,Hata S,and Hashimoto S.
Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma. Front Oncol. 2022 Nov 3;12:1005566.

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Takada, S., Fumoto, Y.(MC), Kinugawa, S.

Ergogenic effects of caffeine are mediated by myokines.Frontiers in sports and active living.4：969623.2022

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Maemoto T, Kitai Y, Takahashi R, Shoji H, Yamada S, Takei S, Ito D, Muromoto R, Kashiwakura J-i, Handa H, Hashimoto A, Hashimoto S, Ose T, Oritani K, Matsuda T.

A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling. The Journal of biological chemistry.102724.2022.

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Takada S, Maekawa S, Furihata T, Kakutani N, Setoyama D, Ueda K, Nambu H, Hagiwara H, Handa H, Fumoto Y, Hata S, Masunaga T, Fukushima A, Yokota T, Kang D, Kinugawa S, Sabe H.

Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure. Proc Natl Acad Sci U S A. 119(41):e2203628119, 2022.

 

Kajihara N, Kobayashi T, Otsuka R, Nio-Kobayashi J, Oshino T, Takahashi M, Imanishi S, Hashimoto A, Wada H, Seino KI.

Tumor-derived interleukin-34 creates an immunosuppressive and chemoresistant tumor microenvironment by modulating myeloid-derived suppressor cells in triple-negative breast cancer. Cancer Immunol Immunother., in press.

 

Hashimoto S, Hashimoto A, Muromoto R, Kitai Y, Oritani K, Matsuda T.

Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance. Cells. 11:2618, 2022.

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Takada S , Sabe H & Kinugawa S.

Treatments for skeletal muscle abnormalities in heart failure: sodium-glucose transporter 2 and ketone bodies. Am J Physiol Heart Circ Physiol. 322: H117-H128, 2022.

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Horikawa M, Sabe H, Onodera Y.

Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX. Transl Oncol. 15:101258, 2022.

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