研究成果
北海道大学大学院医学研究院 分子生物学教室の研究成果
北海道大学大学院医学研究院 分子生物学教室の研究者たちは数多くの論文を発表してきました。当研究所のスタッフによる注目すべき革新的な論文および記事をお読みください。
2023年・2024年の論文
2025年1月24日更新
Ari Hashimoto , and Shigeru Hashimoto
Plasticity and Tumor Microenvironment in Pancreatic Cancer: Genetic, Metabolic, and Immune Perspectives
Cancers: 16(23), 4094; Dec 2024
Yoshizuki Fumoto,Shingo Takada,Yasuhito Onodera,Shigetsugu Hatakeyama,Tsukasa Oikawa
Development of a Myogenin minimal promoter-based system for visualizing the degree of myogenic differentiation
Biochem Biophys Res Commun Volume 741,151091,Nov 2024
Oikawa.T, Hasegawa.J, Handa.H,Ohnishi.N, Onodera.Y, Hashimoto.A,Sasaki.J,Sasaki.T, Ueda.K,and Sabe.H
p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleus
Life Science Alliance:7(9),2024
Natsui.H,Watanabe.M,Yokota.T,Tsuneta.S,Fumoto.Y(DC),Handa.H,Matsushima.S,Koya.J,Nishino.K,Tatsuta.D,Koizumi.T,Kadosaka.T,
Nakao.T,Koya.T,Temma.T,Yoichi.M.Ito,Hatanaka.C.Kanako,Hatanaka.Y,Yasushige.Y,Wakasa.S,Miura.S,Masuda.S,Nishioka.N,Naraoka.S,
Ochi.K,Kudo. T,Ishikawa.T,and Anzai.T
Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery
Physiological Reports;12(6),2024
Naito.S, Tanaka.H, Jiang.JJ, Tarumi.M, Hashimoto.A, Tanaka.Y, Murakami.K, Kubota.SI, Hojyo.S, Hashimoto.S, Murakami.M
DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation
Biochem Biophys Res Commun;703:149666,2024
Mazaki.Y,Handa.H,Fumoto.Y(DC),Horinouchi.T,Onodera.Y
LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity
Cell Commun Signal;21(1):300,2023
Higashi.T,Handa.H,Mai.Y,Maenaka.K,Tadokoro.T
Protein kinase Cβ is involved in cigarette smoke gas phase-induced ferroptosis in J774 macrophages
Journal of Pharmacological Sciences;153(1) 22-25,2023
ADP-Ribosylation Factor 6 Pathway Acts as a Key Executor of Mesenchymal Tumor Plasticity
International Journal of Molecular Sciences;24(19):14934,2023
Yamamoto.R,Yamada.S,Atsumi.T,Murakami.K,Hashimoto.A,Naito.S,Tanaka.Y,Ohki.I, Shinohara.Y,Iwasaki.N,Yoshimura.A, Jing-Jing Jiang,Kamimura.D,Hojyo.S,Kubota.SI, Hashimoto.S, and Murakami.M
Computer model of IL-6 dependent rheumatoid arthritis in F759 mice
International immunology;35(9):403-421,.2023
Shirakawa.R, Nakajima.T, Yoshimura.A, Kawahara .Y, Orito.C, Yamane.M, Handa.H, Takada.S, Furihata.T, Fukushima.A, Ishimori.N, Nakagawa.M, Yokota.I, Sabe.H, Hashino.S, Kinugawa.S, Yokota.T
Enhanced mitochondrial oxidative metabolism in peripheral blood mononuclear cells is associated with fatty liver in obese young adults
Scientific Reports (13),5203 ,2023
Koizumi.T, Watanabe.M, Yokota.T, Tsuda.M, Handa.H, Koya.J, Nishino.K, Tatsuta.D, Natsui.H, Kadosaka.T, Koya.T, Nakao.M, Hagiwara.H, Kamada.R, Temma.T, Tanaka.S, Anzai.T
Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats
Frontiers in Cardiovascular Medicine;10:1005408.2023
Kida.H, Jing-Jing Jiang,Matsui.Y,Takahashi.I, Hasebe.R,Kawamura.D,Endo.T,Shibayama.H,Kondoh.M,Nishio.Y,Nishida.K, Matsuno.Y, Oikawa.T,Kubota.S,Hojyo.S,Iwasaki.N,Hashimoto.S,Tanaka.Y,Murakami.M
Dupuytren’s contracture-associated SNPs increase SFRP4 expression in non-immune cells including fibroblasts to enhance inflammation development
2022年の論文
2022年10月17日更新
Takada.S, Fumoto. Y(DC), Kinugawa. S
Ergogenic effects of caffeine are mediated by myokines
Frontiers in sports and active living.;4：969623.2022
Maemoto.T, Kitai.Y, Takahashi.R, Shoji H, Yamada.S, Takei.S, Ito.D, Muromoto.R, Kashiwakura J-i, Handa.H, Hashimoto.A, Hashimoto.S, Ose.T, Oritani. K, Matsuda.T
A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling
The Journal of biological chemistry;299(1):102724.2022
Hashimoto.A,Handa.H,Hata.S(MC),and Hashimoto.S
Orchestration of mesenchymal plasticity and immune evasiveness via rewiring of the metabolic program in pancreatic ductal adenocarcinoma
Frontiers in oncology; 3:12:1005566.2022
Takada.S,Kinugawa,S,Handa.H, Yokota.T,Sabe.H
Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases
Frontiers in oncology;3:12:1005566 2022
Takada.S,Maekawa.S,Takaaki.F,Kakutani.Naoya,Setoyama.Daiki,Ueda.Koji,Nambu.H, Hagiwara.H,Handa.H, Fumoto.Y(DC), Hata.S(MC),Masunaga.T,Fukushima.A,Yokota.T,Dongchon.K,Kinugawa.S,Sabe.H
Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure
Proceedings of the National Academy of Sciences of the United States of America;119(41):e2203628119.2022
Kajihara.N, Kobayashi.T, Otsuka.R, Nio-Kobayashi.J, Oshino.T, Takahashi.M, Imanishi.S, Hashimoto.A, Wada.H, Seino.KI
Tumor-derived interleukin-34 creates an immunosuppressive and chemoresistant tumor microenvironment by modulating myeloid-derived suppressor cells in triple-negative breast cancer
Cancer Immunol Immunother in press;72(4):851-864.2022
Hashimoto.S, Hashimoto.A, Muromoto.R, Kitai.Y, Oritani.K, Matsuda.T
Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance
Horikawa.M, Sabe.H, Onodera.Y
Dual roles of AMAP1 in the transcriptional regulation and intracellular trafficking of carbonic anhydrase IX