​2021年以前の原著論文

2022年3月31日

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Horikawa M, Sabe H, Onodera Y.

Strategies for all-at-once and stepwise selection of cells with multiple genetic manipulations. Biochem Biophys Res Commun. 582:93-99, 2021.

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Parajuli G, Tekguc M, Wing JB, Hashimoto A, Okuzaki D, Hirata T, Sasaki A, Itokazu T, Handa H,  Sugino H, Nishikawa Y, Metwally H, Kodama Y, Tanaka S, Sabe H, Yamashita T, Sakaguchi S, Kishimoto T & Hashimoto S.

Arid5a promotes immune evasion by augmenting tryptophan metabolism and chemokine expression. Cancer Immunol Res. 9: 862-876, 2021.

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Hashimoto A, Handa H, Hata S, Tsutaho A, Yoshida T, Hirano S, Hashimoto S & Sabe H.

Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer. Cell Commun Signal. 19: 54, 2021.

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Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H & Kinugawa S.

Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol. 4: 138, 2021.

Matsumoto J, Takada S, Furihata T, Nambu H, Kakutani N, Maekawa S, Mizushima W, Nakano I, Fukushima A, Yokota T, Tanaka S, Handa H, Sabe H & Kinugawa S.

Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-activated Protein Kinase-α - Proliferator-Activated Receptor-r Coactivator-1α Signaling in Skeletal Muscle of Mice With Heart Failure. Circ Heart Fail. 14: e005890, 2021.

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Tsutaho A, Hashimoto A, Hashimoto S, Hata S, Kachi S, Hirano S, Sabe H.

High Expression of AMAP1, an ARF6 Effector, Is Associated With Elevated Levels of PD-L1 and Fibrosis of Pancreatic Cancer. Cell Commun Signal. 18: 101, 2020.

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Nambu H, Takada S, Maekawa S, Matsumoto J, Kakutani N, Furihata T, Shirakawa R, Katayama T, Nakajima T, Yamanashi K, Obata Y, Nakano I, Tsuda M, Saito A, Fukushima A, Yokota T, Nio-Kobayashi J, Yasui H, Higashikawa K, Kuge Y, Anzai T, Sabe H, Kinugawa S.

Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovasc Res. cvaa127, 2020.

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Takada S, Sabe H, Kinugawa S.

Abnormalities of Skeletal Muscle, Adipocyte Tissue, and Lipid Metabolism in Heart Failure: Practical Therapeutic Targets. Front Cardiovasc Med. 7: 79, 2020.

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Maekawa S, Takada S, Nambu H, Furihata T, Kakutani N, Setoyama D, Ueyanagi Y, Kang D, Sabe H, Kinugawa S.

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure. Cell Commun Signal. 17: 128, 2019.

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Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G, Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y, Murakami M, Fujiwara T, Hirano S, Sabe H.

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer. Proc Natl Acad Sci U S A. 116: 17450-17459, 2019.

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Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H.

Mitofusin 2 is involved in chemotaxis of neutrophil-like differentiated HL-60 cells. Biochem Biophys Res Commun. 513: 708-713, 2019.

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Nishikawa S, Menju T, Takahashi K, Miyata R, Chen-Yoshikawa TF, Sonobe M, Yoshizawa A, Sabe H, Sato T, Date H.

Statins may have double-edged effects in patients with lung adenocarcinoma after lung resection. Cancer Manag Res. 2019: 3419-3432, 2019.

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Nakano I, Hori H, Fukushima A, Yokota T, Kinugawa S, Takada S, Yamanashi K, Obata Y, itaura Y, Kakutani N, Abe T, Anzai T.

Enhanced Echo Intensity of Skeletal Muscle Is Associated with Exercise Intolerance in Patients with Heart Failure. J Card Fail. 2019(in press).

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Ishikawa K, Fukushima A, Yokota T, Takada S, Furihata T, Kakutani N, Yamanashi, K, Obata Y, Nakano I, Abe T, Kinugawa S, Anzai T.

Clinical Impacts and Associated Factors of Delayed Ambulation in Patients with Acute Heart Failure. Circ Rep. 1: 179-186, 2019.

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Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, NishiharaH, Dela F, Nakanishi K, Matsui Y, Kinugawa S.

Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Sci Rep. 9: 3535, 2019.

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Okita K, Takada S, Morita N, Takahashi M, Hirabayashi K, Yokota T, Kinugawa S.

Resistance training with interval blood flow restriction effectively enhances intramuscular metabolic stress with less ischemic duration and discomfort. Appl Physiol Nutr Metab. 44: 759-764, 2019.

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Kamada R, Yokoshiki H, Mitsuyama H, Watanabe M, Mizukami K, Tenma T, Takahashi M, Takada S, Anzai T.

Arrhythmogenic β-adrenergic signaling in cardiac hypertrophy: the role of small-conductance calcium-activated potassium channels via activation of CaMKII. Eur J Pharmacol. 884: 110-117, 2018.

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Handa H, Hashimoto A, Hashimoto S, Sugino H, Oikawa T, Sabe H.

Epithelial-specific histone modification of the miR-96/182 locus targeting AMAP1 mRNA predisposes p53 to suppress cell invasion in epithelial cells. Cell Commun. Signal. 16: 94, 2018.

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Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T.

Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure. Circulation. 138: 2064-2066, 2018.

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Onodera Y, Nam JM, Horikawa M, Shirato H, Sabe H.

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe. Nat Commun. 9: 2682, 2018.

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Oikawa T, Otsuka Y, Sabe H.

p53-Dependent and -Independent Epithelial Integrity: Beyond miRNAs and Metabolic Fluctuations. Cancers. 10: 162, 2018.

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Tenma T, Mitsuyama H, Watanabe M, Kakutani N, Otsuka Y, Mizukami K, Kamada R, Takahashi M, Takada S, Sabe H, Tsutsui H, Yokoshiki H.

Small-Conductance Ca2+-Activated K+ Channel Activation Deteriorates Hypoxic Ventricular Arrhythmias via CaMKII in Cardiac Hypertrophy. Am J Physiol Heart Circ Physiol. 315: H262-H272, 2018.

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Oikawa, T., Otsuka, Y., Onodera, Y., Horikawa, M., Handa, H., Hashimoto, S., Suzuki, Y., Sabe, H.

Necessity of p53-binding to the CDH1 locus for its expression defines two epithelial cell types differing in their integrity. Sci. Rep. 8: 1595, 2018.

Otsuka, Y., Oikawa, T., Yoshino, H., Hashimoto, S., Handa, H., Yamamoto, H., Hashimoto, A., Sabe, H.

Frequent overexpression of AMAP1, an Arf6 effector in cell invasion, is characteristic of the MMTV-PyMT rather than the MMTV-Neu human breast cancer model. Cell Commun. Signal. 16: 1, 2018.

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Mazaki, Y., Onodera, Y., Higashi, T., Horinouchi, T., Oikawa, T. and Sabe, H.

ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis. Cell Comm. Signal. 15: 36, 2017.

Daimon, T., Kosaka, T., Kikuchi, E., Mikami, S., Miyazaki, Y., Hashimoto, A., Hashimoto, S., Mizuno, R., Miyajima, A., Okada, Y., Sabe, H., Oya, M.

Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma. Urol Oncol. 35: 543.e17-543.e24, 2017.

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Otsuka, Y., Sato, H., Oikawa, T., Onodera, Y., Nam, J.M., Hashimoto, A., Fukunaga, K., Hatanaka, K.C., Hatanaka, Y., Matsuno, Y., Fukuda, S., Sabe, H.

High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue. Cell Comm. Signal. 14: 28, 2016.

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Handa, H., Hashimoto, A., Hashimoto, S., Sabe, H.

Arf6 and its ZEB1-EPB41L5 mesenchymal axis are required for both mesenchymal- and amoeboid-type invasion of cancer cells. Small GTPases 18: 1-7, 2016.

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Tanaka, N., Kosaka, T., Miyazaki, Y., Mikami, S., Niwa, N., Otsuka, Y., Minamishima, Y.A., Mizuno, R., Kikuchi, E., Miyajima, A., Sabe, H., Okada, Y., Uhlen, P., Suematsu, M., Oya, M.

Acquired platinum resistance involves epithelial to mesenchymal transition through ubiquitin ligase FBXO32 dysregulation. JCI Insight 1: e83654.2016.

Hashimoto, A., Hashimoto, S., Sugino, H., Yoshikawa, A., Onodera, Y., Handa, H., Oikawa, T. and Sabe, H.

ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis, and drug resistance. Oncogenesis. 5: e259, 2016.

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Komiya, Y., Onodera, Y., Kuroiwa, M., Nomimura, S., Kubo, Y., Nam, J.M., Kajiwara, K., Nada, S., Oneyama, C., Sabe, H. and Okada, M.

The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition. Oncogenesis. 5: e258, 2016.

Sabe, H., Hashimoto, A,. Hashimoto, S., Oikawa, T.

Tumor responsiveness to statins requires overexpression of the ARF6 pathway. Mol Cell Oncol. 3: e1185564, 2016.

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Hashimoto, A., Oikawa, T., Hashimoto, S., Sugino, H., Yoshikawa, A., Otsuka, Y., Handa, H., Onodera, Y., Nam, J.M., Oneyama, C., Okada, M., Fukuda M. and Sabe, H.

P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance. J Cell Biol. 213: 81-95, 2016.

この論文を取り上げた科学記事：
・In Focus. THE JOURNAL OF CELL BIOLOGY：Arf6 wins the MVP award.
・BREAST CANCER NEWS :Statin May Block Protein Pathway That Promotes Breast Cancer, Study Reports
・medical xpress :How a metabolic pathway promotes breast cancer metastasis
・2017年American Association of Cancer Research(AACR)のOutstanding Paperに選ばれました。（公開され次第、リンクいたします）

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Hashimoto, S,. Mikami, S., Sugino, H., Yoshikawa, A., Hashimoto, A., Onodera, Y., Furukawa, S., Handa, H., Oikawa, T., Okada, Y., Oya, M. and Sabe, H.

Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer. Nat. Commun. 7: 10656, 2016.

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Tien, D.N., Kishihata, M., Yoshikawa, A., Hashimoto, A., Sabe, H., Nishi, E., Kamei, K., Arai, H., Kita, T., Kimura, T., Yokode, M., Ashida, N.

AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions. Sci. Rep. 4: 5094, 2014.

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Hashimoto, S., Hashimoto, A., Sugino, H., Yoshikawa, A., Handa, H., Yoshino, M., Otsuka, Y. amd Sabe, H.

ArfGAPs: not only for the termination.　 In "Ras-superfamily small G-proteins: biology and mechanisms" Vol. 2 pp253-274. (Ed. F. Wittenghofer, Springer Pub.) 2014.

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Sato, H., Hatanaka, KC., Hatanaka, Y., Hatakeyama, H., Hashimoto, A., Matsuno, Y., Fukuda, S., Sabe, H.

High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients. Cell Comm. Signal. 12: 17, 2014.

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Kinoshita, R., Nam, JM., Ito, YM. Hatanaka, KC., Hashimoto, A., Handa, H., Otsuka, Y., Hashimoto, S., Onodera, Y., Hosoda, M., Onodera, S., Shimizu, S., Tanaka, S., Shirato, H., Tanino, M., Sabe, H.

Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy. PLoS One. 8: e76791, 2013.

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Nam, JM., Ahmed, KM., Costes, S., Zhang, H., Onodera, Y., Olshen, AB., Hatanaka, KC., Kinoshita, R., Ishikawa, M., Sabe, H., Shirato, H., Park, CC.

Beta1-integrin via NF-kappaB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer. Breast Cancer Res. 15: R60, 2013.

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Onodera, Y., Nam, JM., Sabe, H.

Intracellular trafficking of integrins in cancer cells. Pharmacol Ther. 140: 1-9, 2013.

Miura, K., Wakayama, Y., Tanino, M., Orba, Y., Sawa, H., Hatakeyama, M., Tanaka, S., Sabe, H., Mochizuki, N.

Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase. Oncogene. 32: 5292-5301, 2013.

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Sabe, H., Onodera, Y., Hashimoto, A., Hashimoto, S.

ASAP1 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 1). Atlas Genet Cytogenet Oncol Haematol. 16: 443-445, 2012.

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Onodera, Y., Nam, JM., Hashimoto, A., Norman, JC., Shirato, H., Hashimoto, S., Sabe, H.

Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion. J Cell Biol. 197: 983-996, 2012. Total citations: 66

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Mazaki, Y., Nishimura, Y., Sabe, H.

GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kg activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production. Mol Biol Cell. 23: 2457-2467, 2012.

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Li, J., Malaby, AW., Famulok, M., Sabe, H., Lambright, DG., Hsu, VW.

Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev Cell. 22: 1286-1298, 2012.

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Wakayama Y, Miura K, Sabe H, Mochizuki N.

EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating ezrin through negative regulation of RhoA. J. Biol. Chem. 286: 44243-44253, 2011.

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Menju, T., Hashimoto, S., Hashimoto, A., Otsuka, Y., Handa, H., Ogawa, E., Toda, Y., Wada, H., Date, H., Sabe, H.

Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma. PLoS One. 6: e25301, 2011.

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Hashimoto, A., Hashimoto, S., Ando, R., Noda, K., Ogawa, E., Kotani, H., Hirose, M., Menju, T., Morishige, M., Manabe, T., Toda, Y., Ishida, S., Sabe, H.

GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis. PLoS One. 6: e23359, 2011.

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Sabe, H.

Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling. J. Biochem. 149: 633-639, 2011.

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Sabe, H., Hashimoto, S., Morishige, M., Ogawa, E., Hashimoto, A., Nam, JM., Miura, K., Yano, H., Onodera, Y.

The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis. Traffic. 10: 982-993, 2009. Total citations: 78

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Miura, K., Nam, JM., Kojima, C., Mochizuki, N., Sabe, H.

EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Mol Biol Cell 20: 1949-1959, 2009. Total citations: 59

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Hirano, M., Hashimoto, S., Yonemura, S., Sabe, H., Aizawa, S.

EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J. Cell Biol. 182: 1217-1230, 2008. Total citations: 67

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Miyata, M., Raven, JF., Baltzis, D., Koromilas, AE., Sabe, H.

IRES-mediated translational control of AMAP1 expression during differentiation of monocyte U937 cells. Cell Cycle. 7: 1-9, 2008.

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Kon, S., Tanabe, K., Watanabe, T., Sabe, H., Satake, M.

Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1. Exp. Cell Res. 314: 1415-1428, 2008.

Bauer, T., Motosugi, N., Miura, K., Sabe, H., Hiiragi, T.

Dynamic rearrangement of surface proteins is essential for cytokinesis. Genesis. 46: 152-162, 2008.

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Sabe, H., Hashimoto, S., Morishige, M., Hashimoto, A., Ogawa, E.

The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside. Cell Adhesion & Migration. 2: 71-73, 2008.

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Morishige, M., Hashimoto, S., Ogawa, E., Toda, Y., Kotani, H., Hirose, M., Wei, S., Hashimoto, A., Yamada, A., Yano, H, Mazaki, Y., Kodama, H., Nio, Y., Manabe, T., Wada, H., Kobayashi, H., Sabe, H.

GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. Nat. Cell Biol. 10: 85-92, 2008. Total citations: 153

この論文を取り上げた科学記事：
・Foley GF. Invasion Signal. Sci Signal. 2008; 1 (1) ec9
・Baumann K. Signalling: The GEP100 pathway to invasion. Nat Rev Cancer. 2008;8:80-1
・Valderrama F, Ridley AJ. Getting invasive with GEP100 and Arf6. Nat Cell Biol. 2008;10(1):16-18.

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Yano, H., Kobayashi, I., Onodera, Y., Luton, F., Franco, M., Mazaki, Y., Hashimoto, S., Iwai, K., Ronai, Z., Sabe, H.

Fbx8 makes Arf6 refractory to function via ubiquitination. Mol. Biol. Cell 19: 822-832, 2008.

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Nam, JM., Onodera, Y., Mazaki, Y., Miyoshi, H., Hashimoto, S., Sabe, H.

CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery. EMBO J. 26: 647-656, 2007. Total citations: 51

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Sabe, H., Onodera, Y., Mazaki, Y., Hashimoto, S.

ArfGAP family proteins in cell adhesion, migration, and tumor invasion. Curr. Opin. Cell Biol. 18: 558-564, 2006. Total citations: 53

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Mazaki, Y., Hashimoto, S., Tsujimura, T., Morishige, M., Hashimoto, A., Aritake, K., Yamada, A., Nam, JM., Kiyonari, H., Nakao, K., Sabe, H.

Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nat. Immunol. 7: 724-731, 2006. Total citations: 60

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Hashimoto, S., Hirose, M., Hashimoto, A., Morishige, M., Yamada, A., Hosaka, H., Akagi, K., Ogawa, E., Oneyama, C., Agatsuma, T., Okada, M., Kobayashi, H., Wada, H., Nakano, H., Ikegami, T., Nakagawa, A., Sabe, H.

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc. Natl. Acad. Sci. U S A. 103: 7036-7041, 2006. Total citations: 78

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Hashimoto, S., Hashimoto, A., Yamada, A., Onodera, Y., Sabe, H.

Assays and properties of ArfGAPs, AMAP1 and AMAP2, in Arf6 function. Methods Enzymol. 404: 216-231, 2005.

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Onodera, Y., Hashimoto, S., Hashimoto, A., Morishige, M., Mazaki, Y., Yamada, A., Ogawa, E., Adachi, M., Sakurai, T., Manabe, T., Wada, H., Matsuura, N., Sabe, H.

Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. EMBO J. 24: 963-973, 2005. Total citations: 118

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Woods, AJ., Kandidakis, T., Sabe, H., Critchley, DR., Norman, JC.

Interaction of paxillin with poly(A)-binding protein 1: a role in focal adhesion turnover and cell migration. Mol. Cell Biol. 25: 3763-3773, 2005.

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Kojima, C., Hashimoto, A., Yabuta, I., Hirose, M., Hashimoto, S., Kanaho, Y., Sumimoto, H., Ikegami, T., Sabe, H.

Regulation of Bin1 SH3 domain binding by phosphoinositides. EMBO J. 23: 4413-4422, 2004.

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Yano, H., Mazaki, Y., Kurokawa, K., Hanks, SK., Matsuda, M., Sabe, H.

Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J. Cell Biol. 166: 283-295, 2004. Total citations: 184

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Romanova, LY., Hashimoto. S., Chay, KO., Blagosklonny, MV., Sabe, H., Mushinski, JF.

Phosphorylation of paxillin tyrosines 31 and 118 controls polarization and motility of lymphoid cells and is PMA-sensitive. J. Cell Sci. 117: 3759-3768, 2004.

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Hashimoto, S., Hashimoto, A., Yamada, A., Kojima, C., Yamamoto, H., Tsutsumi, T., Higashi, M., Mizoguchi, A., Yagi, R., Sabe, H.

A novel mode of action of an ArfGAP, AMAP2/PAG3/Papalpha, in Arf6 function. J. Biol. Chem. 279: 37677-37684, 2004.

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Hashimoto, S., Onodera, Y., Hashimoto, A., Tanaka, M., Hamaguchi, M., Yamada, A., Sabe, H.

Requirement for Arf6 in breast cancer invasive activities. Proc. Natl. Acad. Sci. U S A. 101: 6647-6652, 2004. Total citations: 198

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Watanabe, H., Shimizu, T., Nishihira, J., Abe, R., Nakayama, T., Taniguchi, M., Sabe, H., Ishibashi, T., Shimizu, H.

Ultraviolet A-induced production of matrix metalloproteinase-1 is mediated by macrophage migration inhibitory factor (MIF) in human dermal fibroblasts. J. Biol. Chem. 279: 1676-1683, 2004.
Total citations: 78

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Sabe H.

Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion. (Minireview) J. Biochem. (Tokyo) 134: 485-489, 2003.

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Sabe H.

Paxillin-associated ArfGAPs: their isoform specificities and roles in coordination. In Protein and Cell Regulation. 'ARF Family GTPases' (2003); vol.1:pp185-207. (Ed. Kahn R; Series editors: Ridney A, Frampton J; Kluwer Academic Publishers).

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Didier C, Broday L, Bhoumik A, Israeli S, Takahashi S, Nakayama K, Thomas SM, Turner CE, Henderson S, Sabe H, Ronai Z.

RNF5 - a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Mol. Cell Biol. 23: 5331-5345, 2003. Total citations: 74

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Yamamoto Y, Maruyama T, Sakai N, Sakurai R, Shimizu A, Hamatani T, Masuda H, Uchida H, Sabe H, Yoshimura Y.

Expression and subcellular distribution of the active form of c-Src tyrosine kinase in differentiating human endometrial stromal cells. Mol. Hum. Reprod. 8: 1117-1124, 2002.

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Sabe H.

Ensemble of membrane and cytoskeleton remodelings in cell migration Seikagaku.74: 1429-1440, 2002. (In Japanese)

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Tsubouchi A, Sakakura J, Yagi R, Mazaki Y, Schaefer E, Yano H, Sabe H.

Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration. J. Cell Biol. 159: 673-683, 2002. Total citations: 137

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Oshiro T, Koyama S, Sugiyama S, Kondo A, Onodera Y, Asahara T, Sabe H, Kikuchi A.

Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration. J. Biol. Chem. 277: 38618-38626, 2002.

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Iwasaki T, Nakata A, Mukai M, Shinkai K, Yano H, Sabe H, Schaefer E, Tatsuta M, Tsujimura T, Terada N, Kakishita E, Akedo H.

Involvement of phosphorylation of Tyr-31 and Tyr-118 of paxillin in MM1 cancer cell migration. Int. J. Cancer 97: 330-335, 2002.

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Woods AJ, Roberts MS, Choudhary J, Barry ST, Mazaki Y, Sabe H, Morley SJ, Critchley DR, Norman JC.

Paxillin associates with poly(A)-binding protein 1 at the dense endoplasmic reticulum and the leading edge of migrating cells. J. Biol. Chem. 277: 6428-6437, 2002. Total citations: 81

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Yagi R, Ishimaru S, Yano H, Gaul U, Hanafusa H, Sabe H.

A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila. EMBO Rep. 2: 814-820, 2001.

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Nakamura K, Yano H, Schaefer E, Sabe H.

Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies. Oncogene. 20: 2626-2635, 2001. Total citations: 66

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Uchida H, Kondo A, Yoshimura Y, Mazaki Y, Sabe H.

PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages. J. Exp. Med. 193: 955-966, 2001.

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Mazaki Y, Hashimoto S, Okawa K, Tsubouchi A, Nakamura K, Yagi R, Yano H, Kondo A, Iwamatsu A, Mizoguchi A, Sabe H.

An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. Mol. Biol. Cell 12: 645-662, 2001.
Total citations: 73

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Hashimoto S, Tsubouchi A, Mazaki Y, Sabe H.

Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3. J. Biol. Chem. 276: 6037-6045, 2001.

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Suzuki, A., Kadota, N., Hara, T., Nakagami, Y., Izumi, T., Takenawa, T., Sabe, H., Endo, T.

Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src. Oncogene. 19: 5842-5850, 2000.

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Yano, H., Uchida, H., Iwasaki, T., Mukai, M., Akedo, H., Nakamura, K., Hashimoto, S., Sabe, H.

Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation. Proc. Natl. Acad. Sci. U S A. 97: 9076-9081, 2000.
Total citations: 75

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Nakamura, K., Yano, H., Uchida, H., Hashimoto, S., Schaefer, E., Sabe, H.

Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells. J. Biol. Chem. 275: 27155-27164, 2000.

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Kanazawa, T., Nakamura, S., Momoi, M., Yamaji, T., Takematsu, H., Yano, H., Sabe, H., Yamamoto, A., Kawasaki, T., Kozutsumi, Y.

Inhibition of cytokinesis by a lipid metabolite, psychosine. J. Cell Biol. 149: 943-950, 2000.
Total citations: 74

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Kondo, A., Hashimoto, S., Yano, H., Nagayama, K., Mazaki, Y., Sabe, H.

A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration. Mol. Biol. Cell 11: 1315-1327, 2000. Total citations: 92

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Ito, A., Kataoka, T.R., Watanabe, M., Nishiyama, K., Mazaki, Y., Sabe, H., Kitamura, Y., Nojima, H.

A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J. 19: 562-571, 2000. Total citations: 127

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【番外】　Sabe H, Hata A, Okada M, Nakagawa H, Hanafusa H.

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src. Proc. Natl. Acad. Sci. USA. 91: 3984-3988, 1994.
Total citations: 194

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【番外】　Sabe H, Knudsen B, Okada M, Nada S, Nakagawa H, Hanafusa H.

Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein. Proc. Natl. Acad. Sci. USA. 89: 2190-2194, 1992. Total citations: 82